Parmeggiani, Huang et al. 2015 (Baker Lab) - Journal of Molecular Biology
- Repeat proteins useful as binding reagents or biomaterials for various applications
- General method for building idealized repeats - combines sequence & structural information with de novo protein design calculations
- Idealized designs from six protein families were experimentally characterized: 80% souble, 40% folded and monomeric with high thermal stability
- Crystal structures are within 1Å of designs
- General, reliable and fast generation of stable, modular repeat scaffolds
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| Graphical Abstract from paper |
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