Putnam et al. 2015 - Proteins: Structure, Function, Bioinformatics
(Paper from Meiler Lab)
- SAXS: Small angle x-ray scattering used to characterize structures in solution
- Algorithm that can replicate SAXS profiles
- Abilities of the algorithm:
- Represent complete models
- Models with approximated side chain coordinates
- Models with approximated side chain and loop region coordinates
- Algorithm can identify the correct SAXS profile and protein topology with 99% accuracy (ROC Area)
- Can be used to as a filter to exclude models with large structural differences from the native
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